Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Targeted drug and gene delivery is the key for precision therapy. Lipid nanoparticles as non-
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …

Tremendous progress has been made in the field of toxicology leading to the advance of
developmental toxicity assessment. Conventional animal models and in vitro two …

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …

At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

Thanks to progress in the development of three‐dimensional (3D) culture technologies,
human central nervous system (CNS) development and diseases have been gradually …

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their
potential to expand and differentiate into virtually any cell type and recapitulate key aspects …