B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …

T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that
mediates recognition of pathogen-associated epitopes through interactions with peptide and …

B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …

Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

The variable domain of an immunoglobulin (IG) sequence is encoded by multiple genes,
including the variable (V) gene, the diversity (D) gene and the joining (J) gene. Analysis of …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org) is the
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …

Antibody responses to viral infections are sustained for decades by long-lived plasma cells
(LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19 …

Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …

Abstract T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune
disease pathogenesis,,. They are most abundant in the small intestine lamina propria, where …