Temporary postoperative cardiac pacing requires devices with percutaneous leads and
external wired power and control systems. This hardware introduces risks for infection …

Small animals support a wide range of pathological phenotypes and genotypes as versatile,
affordable models for pathogenesis of cardiovascular diseases and for exploration of …

Aims Invaginations of the cellular membrane called t-tubules are essential for maintaining
efficient excitation–contraction coupling in ventricular cardiomyocytes. Disruption of t-tubule …

Pressure overload-induced TGF-β signaling activates cardiac fibroblasts (CFB) and leads to
increased extracellular matrix (ECM) protein synthesis including fibrosis. Excessive ECM …

Aims Concentric hypertrophy following pressure-overload is linked to preserved systolic
function but impaired diastolic function, and is an important substrate for heart failure with …

The use of MR imaging and spectroscopy for studying cardiovascular disease processes in
small animals has increased tremendously over the past decade. This is the result of the …

Cardiovascular magnetic resonance (CMR) imaging has become an accurate and versatile
imaging modality to visualize the cardiovascular system in normal or abnormal conditions. In …

Heart failure is a major cause of morbidity and mortality worldwide, and can result from
pressure overload, where cardiac remodelling is characterized by cardiomyocyte …

Background: Obesity is an increasingly prevalent metabolic disorder in the modern world
and is associated with structural and functional changes in the heart. The NLRP3 …

Aims Regional heterogeneities in contraction contribute to heart failure with reduced
ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial …