Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …

The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …

Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome
condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the superfamily …

Transcription-translation coupling leads to the production of proteins that are key for
controlling essential neuronal processes that include neuronal development and changes in …

The genetic basis of schizophrenia (SZ) remains elusive despite its characterization as a
highly heritable disorder. This incomplete understanding has led to stagnation in …

Abstract The RAF/MEK/ERK cascade is a conserved intracellular signaling pathway that
controls fundamental cellular processes including growth, proliferation, differentiation …

Simple Summary Breast cancer has the highest incidence and mortality in women
worldwide, and, despite formidable advances in its prevention, detection, and treatment, the …

Apomorphine is a dopamine receptor agonist that activates D 1–D 5 dopamine receptors
and that is used to treat Parkinson's disease (PD). However, the effect of apomorphine on …

A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and
unstable gait in tambaleante (tbl) mice. Recently, we have shown that before cerebellar …

Ubiquitin ligases are important regulators of nervous system development, function and
disease. To date, numerous ubiquitin ligases have been discovered that regulate …