The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …
which initiates rapid signal transmission in the synapse before its re-uptake into the …
Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder
Y Xiong, J Chen, Y Li - Frontiers in Neuroscience, 2023 - frontiersin.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …
Pathology and astrocytes in autism
G Vakilzadeh, V Martinez-Cerdeño - Neuropsychiatric Disease and …, 2023 - Taylor & Francis
A distinct pathology for autism spectrum disorder (ASD) remains elusive. Human and animal
studies have focused on investigating the role of neurons in ASD. However, recent studies …
studies have focused on investigating the role of neurons in ASD. However, recent studies …
Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …
class of cells as integral to function and dysfunction of the nervous system. In particular …
Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance …
L Tebartz van Elst, S Maier, T Fangmeier… - Molecular …, 2014 - nature.com
Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …
[HTML][HTML] Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment
A Taleb, W Lin, X Xu, G Zhang, QG Zhou… - Biomedicine & …, 2021 - Elsevier
Autism spectrum disorder (ASD) is a sort of mental disorder marked by deficits in cognitive
and communication abilities. To date no effective cure for this pernicious disease has been …
and communication abilities. To date no effective cure for this pernicious disease has been …
Astrocyte heterogeneity in the brain: from development to disease
C Schitine, L Nogaroli, MR Costa… - Frontiers in cellular …, 2015 - frontiersin.org
In the last decades, astrocytes have risen from passive supporters of neuronal activity to
central players in brain function and cognition. Likewise, the heterogeneity of astrocytes …
central players in brain function and cognition. Likewise, the heterogeneity of astrocytes …
Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling
The generation of astrocytes from human induced pluripotent stem cells has been hampered
by either prolonged differentiation—spanning over two months—or by shorter protocols that …
by either prolonged differentiation—spanning over two months—or by shorter protocols that …
The impact of glutathione metabolism in autism spectrum disorder
This paper reviews the potential role of glutathione (GSH) in autism spectrum disorder
(ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance …
(ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance …
[HTML][HTML] Memantine/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal CREB/BDNF signaling and glutamate …
Significant efforts are increasingly directed towards identifying novel therapeutic targets for
autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in …
autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in …