With an estimated 9.4 million new cases globally, tuberculosis (TB) continues to be a major
public health concern. Eighty percent of all cases worldwide occur in 22 high-burden, mainly …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

Experimental genomics in combination with the growing body of sequence information
promise to revolutionize the way cells and cellular processes are studied. Information on …

Experimental genomics involves taking advantage of sequence information to investigate
and understand the workings of genes, cells and organisms. We have developed an …

Nonpigmented and late-pigmenting rapidly growing mycobacteria (RGM) are increasingly
isolated in clinical microbiology laboratories. Their accurate identification remains …

The detection of viral pathogens is of critical importance in biology, medicine, and
agriculture. Unfortunately, existing techniques to screen for a broad spectrum of viruses …

For the differentiation and identification of mycobacterial species, the rpoB gene, encoding
the β subunit of RNA polymerase, was investigated. rpoB DNAs (342 bp) were amplified …

We have established high resolution methods for global monitoring of gene expression in
Escherichia coli. Hybridization of radiolabeled cDNA to spot blots on nylon membranes was …

Detection and diagnosis of plant viruses has included serological laboratory tests since the
1960s. Relatively little work was done on serological detection of plant pathogenic bacteria …

van Soolingen D (National Institute of Public Health and the Environment, Bilthoven, The
Netherlands). Molecular epidemiology of tuberculosis and other mycobacterial infections …