Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration
Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic
neuronal function. However, alterations in calcium homeostasis lead to persistent …
neuronal function. However, alterations in calcium homeostasis lead to persistent …
Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD)
suggest that the disease progresses over time. The worsening neuropathology may involve …
suggest that the disease progresses over time. The worsening neuropathology may involve …
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
R Deogracias, M Yazdani… - Proceedings of the …, 2012 - National Acad Sciences
The functional relevance of brain-derived neurotrophic factor (BDNF) is beginning to be well
appreciated not only in mice, but also in humans. Because reduced levels typically correlate …
appreciated not only in mice, but also in humans. Because reduced levels typically correlate …
[HTML][HTML] Biomarkers for acute diagnosis and management of stroke in neurointensive care units
OY Glushakova, AV Glushakov, ER Miller… - Brain …, 2016 - journals.lww.com
The effectiveness of current management of critically ill stroke patients depends on rapid
assessment of the type of stroke, ischemic or hemorrhagic, and on a patient's general …
assessment of the type of stroke, ischemic or hemorrhagic, and on a patient's general …
Bipolar disorder and mechanisms of action of mood stabilizers
Bipolar disorder (BD) is a major medical and social burden, whose cause, pathophysiology
and treatment are not agreed on. It is characterized by recurrent periods of mania and …
and treatment are not agreed on. It is characterized by recurrent periods of mania and …
Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95
S Gascón, M Sobrado, JM Roda… - Molecular …, 2008 - nature.com
The N-methyl-D-aspartate receptor (NMDAR) is central to physiological and pathological
functioning of neurons. Although promising results are beginning to be obtained in the …
functioning of neurons. Although promising results are beginning to be obtained in the …
[图书][B] Biology of the NMDA Receptor
AM VanDongen - 2008 - taylorfrancis.com
The NMDA receptor plays a critical role in the development of the central nervous system
and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this …
and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this …
[HTML][HTML] Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
A better understanding of the mechanisms underlying neuronal death in cerebral ischemia
is required for the development of stroke therapies. Here we analyze the contribution of the …
is required for the development of stroke therapies. Here we analyze the contribution of the …
Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory
PF Simoes, AP Silva, FC Pereira, E Marques, S Grade… - Neuroscience, 2007 - Elsevier
Methamphetamine (METH) is a powerful psychostimulant that increases glutamate (Glu)
levels in the mammalian brain and it is currently known that hippocampi are particularly …
levels in the mammalian brain and it is currently known that hippocampi are particularly …