There is substantial epidemiological and experimental evidence of an obesity-related
asthma phenotype. Compared to children of healthy weight, children with obesity are at …

Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …

Biobanks often contain several phenotypes relevant to diseases such as major depressive
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …

We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

To the Editor: In individuals with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection, the severity of illness ranges from asymptomatic to fatal. 1 The Centers for …

Objective We aimed to examine the associations of obesity-related traits (body mass index
[BMI], central obesity) and their genetic predisposition with the risk of developing severe …