Sepsis is a common consequence of infection, associated with a mortality rate> 25%.
Although community-acquired sepsis is more common, hospital-acquired infection is more …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Background Inter-individual variability during sepsis limits appropriate triage of patients.
Identifying, at first clinical presentation, gene expression signatures that predict subsequent …

脓毒症是一种源于感染, 以炎症反应和免疫功能紊乱为演变特征, 表现为多脏器功能障碍且具有
高度异质性的综合征. 脓毒症生物标志物是指病原微生物侵入机体后, 在生理, 生化 …

Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …

As the capacity for generating large-scale molecular profiling data continues to grow, the
ability to extract meaningful biological knowledge from it remains a limitation. Here, we …

Intensive care unit (ICU) practitioners and emergency department clinicians are in urgent
need of a major upgrade in their access to accurate and fast microbial diagnosis (Table 1) …

Purpose Early accurate diagnosis of infection±organ dysfunction (sepsis) remains a major
challenge in clinical practice. Utilizing effective biomarkers to identify infection and …

Purpose This is the second article in a 2-part series discussing the pathophysiology of
sepsis. Part 1 of the series reviewed the immunologic response and overlapping pathways …