Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

The development of B and T cells from hematopoietic precursors and the regulation of the
functions of these immune cells are complex processes that involve highly regulated …

We report the results of GUIDANCE-01 (NCT04025593), a randomized, phase II trial of R-
CHOP alone or combined with targeted agents (R-CHOP-X) guided by genetic subtyping of …

Follicular lymphoma (FL) is a clinically and molecularly heterogeneous disease.
Posttreatment surrogate end points, such as progression of disease within 24 months …

The genes encoding the histone acetyl-transferases (HATs) CREB binding protein
(CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal …

Genome-wide profiling of histone modifications can provide systematic insight into the
regulatory elements and programs engaged in a given cell type. However, conventional …

Deregulation of histone deacetylase (HDAC) is important in the pathogenesis of follicular
lymphoma (FL) and diffuse large B‐cell lymphoma (DLBCL). Mocetinostat, an isotype …

Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and
inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been …

Due to heterogeneous morphological and immunophenotypic features, approximately 50%
of peripheral T-cell lymphomas are unclassifiable and categorized as peripheral T-cell …

Adult T-cell leukemia lymphoma (ATLL) is a rare T cell neoplasm that is endemic in
Japanese, Caribbean, and Latin American populations. Most North American ATLL patients …