[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
[HTML][HTML] Histone acetyltransferases and histone deacetylases in B-and T-cell development, physiology and malignancy
L Haery, RC Thompson, TD Gilmore - Genes & cancer, 2015 - ncbi.nlm.nih.gov
The development of B and T cells from hematopoietic precursors and the regulation of the
functions of these immune cells are complex processes that involve highly regulated …
functions of these immune cells are complex processes that involve highly regulated …
Genetic subtype-guided immunochemotherapy in diffuse large B cell lymphoma: The randomized GUIDANCE-01 trial
MC Zhang, S Tian, D Fu, L Wang, S Cheng, HM Yi… - Cancer Cell, 2023 - cell.com
We report the results of GUIDANCE-01 (NCT04025593), a randomized, phase II trial of R-
CHOP alone or combined with targeted agents (R-CHOP-X) guided by genetic subtyping of …
CHOP alone or combined with targeted agents (R-CHOP-X) guided by genetic subtyping of …
Clinicogenetic risk models predict early progression of follicular lymphoma after first-line immunochemotherapy
V Jurinovic, R Kridel, AM Staiger… - Blood, The Journal …, 2016 - ashpublications.org
Follicular lymphoma (FL) is a clinically and molecularly heterogeneous disease.
Posttreatment surrogate end points, such as progression of disease within 24 months …
Posttreatment surrogate end points, such as progression of disease within 24 months …
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth
H Hashwah, CA Schmid, S Kasser… - Proceedings of the …, 2017 - National Acad Sciences
The genes encoding the histone acetyl-transferases (HATs) CREB binding protein
(CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal …
(CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal …
A multiplexed system for quantitative comparisons of chromatin landscapes
Genome-wide profiling of histone modifications can provide systematic insight into the
regulatory elements and programs engaged in a given cell type. However, conventional …
regulatory elements and programs engaged in a given cell type. However, conventional …
A phase 2 study of mocetinostat, a histone deacetylase inhibitor, in relapsed or refractory lymphoma
CL Batlevi, M Crump, C Andreadis… - British journal of …, 2017 - Wiley Online Library
Deregulation of histone deacetylase (HDAC) is important in the pathogenesis of follicular
lymphoma (FL) and diffuse large B‐cell lymphoma (DLBCL). Mocetinostat, an isotype …
lymphoma (FL) and diffuse large B‐cell lymphoma (DLBCL). Mocetinostat, an isotype …
Precision targeting with EZH2 and HDAC inhibitors in epigenetically dysregulated lymphomas
Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and
inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been …
inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been …
[HTML][HTML] Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified
MM Ji, YH Huang, JY Huang, ZF Wang, D Fu… - …, 2018 - ncbi.nlm.nih.gov
Due to heterogeneous morphological and immunophenotypic features, approximately 50%
of peripheral T-cell lymphomas are unclassifiable and categorized as peripheral T-cell …
of peripheral T-cell lymphomas are unclassifiable and categorized as peripheral T-cell …
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies
Adult T-cell leukemia lymphoma (ATLL) is a rare T cell neoplasm that is endemic in
Japanese, Caribbean, and Latin American populations. Most North American ATLL patients …
Japanese, Caribbean, and Latin American populations. Most North American ATLL patients …