COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …

In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …

Background: High blood pressure has been associated with an increased risk of developing
cognitive impairment. However, this relationship is unclear. This study aims to systematically …

Vascular contributions to cognitive impairment are receiving heightened attention as
potentially modifiable factors for dementias of later life. These factors have now been linked …