Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It
affects nearly 95% of all protein-coding genes and occurs in nearly all human organs …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …

In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene
expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into …

Nuclear speckles are nuclear membraneless organelles in higher eukaryotic cells playing a
vital role in gene expression. Using an in situ reverse transcription–based sequencing …

Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …

Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …

Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus associated with multiple cancers
and autoimmune diseases. Unlike most herpesviruses, EBV reactivation from latency occurs …

MicroRNAs (miRNAs) play crucial roles in regulating plant development and stress
responses. However, the functions and mechanism of intronic miRNAs in plants are poorly …

Recent landmark discoveries have underpinned the physiological importance of intron
retention (IR) across multiple domains of life and revealed an unexpected breath of functions …