Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The
production and deposition of Aβ are important factors affecting AD progression and …

Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …

The amyloid hypothesis has yielded a series of well-validated candidate drug targets with
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …