Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition
in Alzheimer's disease, was incorporated into the latest National Institute of Ageing …

The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's
Disease pathogenesis are not fully understood. To explore these associations in vivo, we …

Background and purpose Recommendations for using fluorodeoxyglucose positron
emission tomography (FDG‐PET) to support the diagnosis of dementing neurodegenerative …

The complexity of Alzheimer's disease (AD) and its long prodromal phase poses challenges
for early diagnosis and yet allows for the possibility of the development of disease modifying …

Amyloid deposition, tangle formation, neuroinflammation and neuronal dysfunction are
pathological processes involved in Alzheimer's disease. However, the relative role of these …

Abstract See Sorg and Grothe (doi: 10.1093/brain/awv302) for a scientific commentary on
this article. In its original form, the amyloid cascade hypothesis of Alzheimer's disease holds …

Aim To assess the clinical utility of FDG-PET as a diagnostic aid for differentiating
Alzheimer's disease (AD; both typical and atypical forms), dementia with Lewy bodies (DLB) …