Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

The present work aims to examine the worrying problem of antibiotic resistance and the
emergence of multidrug-resistant bacterial strains, which have now become really common …

Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant infections. The …

Background Antimicrobial-resistant infections are commonly encountered in US hospitals
and result in significant morbidity and mortality. This guidance document provides …

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …

Members of the genus Klebsiella have rapidly evolved within the past decade, generating
organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR …