The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

The use of artificial intelligence (AI) and machine learning (ML) in pharmaceutical research
and development has to date focused on research: target identification; docking-, fragment …

Understanding the role of water in biological processes remains a central challenge in the
life sciences. Water structures in hydration shells of biomolecules are difficult to study in situ …

Methyl groups can have profound effects in drug discovery but the underlying mechanisms
are diverse and incompletely understood. Here we report the stereospecific effect of a …

G protein-coupled receptors (GPCRs) shift between inactive non-signalling states and active
signalling states, to which intracellular binding partners can bind. Extracellular binding of …

Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …

High‐resolution crystal structures highlight the importance of water networks in protein–
ligand interactions. However, as these are typically determined at cryogenic temperature …

The discovery and clinical implementation of modulators of adenosine, P2Y and P2X
receptors (comprising nineteen subtypes) have progressed dramatically in∼ 50 years since …

The available drugs against coronavirus disease 2019 (COVOD-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are limited. This study aimed to …

Patients with nephrotic syndrome (NS) suffer from urinary loss of albumin. As a cause,
previous studies focused on the glomerular filter rather than analyzing the molecular …