ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism
characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency …

Background Remethylation defects are rare inherited disorders in which impaired
remethylation of homocysteine to methionine leads to accumulation of homocysteine and …

Triple-negative breast cancer (TNBC) is characterized by a more aggressive clinical course
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …