Humans are unable to synthesise l‐ascorbic acid (L‐AA, ascorbate, vitamin C), and are thus
entirely dependent upon dietary sources to meet needs. In both plant and animal …

Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Disulfide bond formation is probably involved in the biogenesis of approximately one third of
human proteins. A central player in this essential process is protein disulfide isomerase or …

Although ascorbic acid is an important water‐soluble antioxidant and enzyme cofactor in
plants and animals, humans and some other species do not synthesize ascorbate due to the …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Our concept of how disulfides form in proteins entering the secretory pathway has changed
dramatically in recent years. The discovery of endoplasmic reticulum (ER) oxidoreductin 1 …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …

Dehydroascorbic acid (DHA) is an important, interesting but somewhat enigmatic compound
in biological systems. DHA has many unique properties that set it apart from ascorbic acid …

During hibernation in Arctic ground squirrels (Spermophilus parryii), O2 consumption and
plasma leukocyte counts decrease by> 90%, whereas plasma concentrations of the …

In most aerobic organisms hemoperoxidases play a major role in H2O2-detoxification, but
trypanosomatids have been reported to lack this activity. Here we describe the properties of …