The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

Natural killer (NK) cells are innate immune effector cells that make up~ 10-15% of the
peripheral blood lymphocytes in humans and are primarily involved in immunosurveillance …

T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance
engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells …

Engineered T cells are effective therapies against a range of malignancies, but current
approaches rely on autologous T cells, which are difficult and expensive to manufacture …

Natural killer (NK) cells provide defense in the early stages of the innate immune response
against viral infections by producing cytokines and causing cytotoxicity 1. The killer …

The presence and expression of killer inhibitory receptor (KIR) and CD94: NKG2 genes from
68 donors were analyzed using molecular typing techniques. The genes encoding CD94 …

Because of the expression of inhibitory receptors (KIR) for major histocompatibility complex
(MHC) class I allotypes, a person's natural killer (NK) cells will not recognize and will …

Melanoma lines MEL. A and MEL. B were derived from metastases removed from patient
LB33 in 1988 and 1993, respectively. The MEL. A cells express several antigens recognized …

We analyzed 112 patients with high-risk acute myeloid leukemia (61 in complete remission
[CR]; 51 in relapse), who received human leukocyte-antigen (HLA)–haploidentical …

NK cells are emerging as new effectors for immunotherapy of cancer. In particular, the
genetic engraftment of chimeric Ag receptors (CARs) in NK cells is a promising strategy to …