Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and developing world. Increased …

Background Numerous diseases have been related with free radicals overproduction and
oxidative stress. Botanical preparations possess a multitude of bioactive properties …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than
half of the over 65 population. In the past, OA was considered a wear and tear disease …

Cell senescence is a chronic process associated with age-related degenerative diseases
such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and …

Background Ageing-related failure of homeostasis mechanisms contributes to articular
cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are …

Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …

Nutraceuticals are dietary compounds which have a role in the balance of anabolic and
catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism …