Parkinson disease
R Balestrino, AHV Schapira - European journal of neurology, 2020 - Wiley Online Library
Parkinson disease (PD) is the most common neurodegenerative movement disorder. In
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …
[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …
Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease
J Nowell, E Blunt, P Edison - Molecular Psychiatry, 2023 - nature.com
Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
SIRT1 pathway in Parkinson's disease: a faraway snapshot but so close
GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …
Long-term outcomes of deep brain stimulation in Parkinson disease
P Limousin, T Foltynie - Nature Reviews Neurology, 2019 - nature.com
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …
Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers
Computational drug repurposing aims to identify new indications for existing drugs by
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …
Apoptosis and its therapeutic implications in neurodegenerative diseases
NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
Parkinson's disease predisposing LRRK2 kinase phosphorylates a group of Rab GTPase
proteins including Rab29, within the effector‐binding switch II motif. Previous work indicated …
proteins including Rab29, within the effector‐binding switch II motif. Previous work indicated …
Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes
J Lee, HJ Kim - Frontiers in aging neuroscience, 2022 - frontiersin.org
Aging is accompanied by many changes in brain and contributes to progressive cognitive
decline. In contrast to pathological changes in brain, normal aging brain changes have …
decline. In contrast to pathological changes in brain, normal aging brain changes have …
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells
There is increasing evidence for a cerebellar contribution to cognitive processing, but the
specific input pathways conveying this information remain unclear. We probed the role of …
specific input pathways conveying this information remain unclear. We probed the role of …