Application of zirconium MOFs in drug delivery and biomedicine
Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage
capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for …
capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for …
DNA sequencing at 40: past, present and future
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …
have already witnessed multiple technological revolutions and a growth in scale from a few …
[HTML][HTML] Global detection of human variants and isoforms by deep proteome sequencing
An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …
from a single sample. However, individual proteins are typically identified by peptide …
[HTML][HTML] eccDNAs are apoptotic products with high innate immunostimulatory activity
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature
for several decades, and are known for their broad existence across different species …
for several decades, and are known for their broad existence across different species …
Chromothripsis drives the evolution of gene amplification in cancer
Focal chromosomal amplification contributes to the initiation of cancer by mediating
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …
[HTML][HTML] The structure, function and evolution of a complete human chromosome 8
The complete assembly of each human chromosome is essential for understanding human
biology and evolution,. Here we use complementary long-read sequencing technologies to …
biology and evolution,. Here we use complementary long-read sequencing technologies to …
Multi-omic measurements of heterogeneity in HeLa cells across laboratories
Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …
but most of the focus is on removing the latter. Here we investigate the effects of biological …
Single-cell RNA-seq: advances and future challenges
AE Saliba, AJ Westermann, SA Gorski… - Nucleic acids …, 2014 - academic.oup.com
Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …
lifespan and this variation is reflected in their molecular composition such as the …
Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions
Genomes assembled de novo from short reads are highly fragmented relative to the finished
chromosomes of Homo sapiens and key model organisms generated by the Human …
chromosomes of Homo sapiens and key model organisms generated by the Human …
[PDF][PDF] PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins
DG McEwan, D Popovic, A Gubas, S Terawaki… - Molecular cell, 2015 - cell.com
The lysosome is the final destination for degradation of endocytic cargo, plasma membrane
constituents, and intracellular components sequestered by macroautophagy. Fusion of …
constituents, and intracellular components sequestered by macroautophagy. Fusion of …