Application of neurotoxin-induced animal models in the study of Parkinson's disease-related depression: profile and proposal
YK Mou, LN Guan, XY Yao, JH Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Depression can be a non-motor symptom, a risk factor, and even a co-morbidity of
Parkinson's disease (PD). In either case, depression seriously affects the quality of life of PD …
Parkinson's disease (PD). In either case, depression seriously affects the quality of life of PD …
Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?
HS Lindgren, SB Dunnett - European Journal of Neuroscience, 2012 - Wiley Online Library
Parkinson's disease (PD) has for decades been considered a pure motor disorder and its
cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) …
cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) …
Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission
X Zhang, W Huang, P Tang, Y Sun, X Zhang, L Qiu… - Neurotoxicology, 2021 - Elsevier
Accumulating evidences suggest that inflammation-mediated neurons dysfunction
participates in the initial and development of Parkinson's disease (PD), whereas …
participates in the initial and development of Parkinson's disease (PD), whereas …
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling …
J Li, J Yu, J Guo, J Liu, G Wan, X Wei… - Pharmaceutical …, 2023 - Taylor & Francis
Context Levodopa combined with traditional Chinese medicine has a synergistic effect on
Parkinson's disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) …
Parkinson's disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) …
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide …
Modeling Parkinson's disease remains a major challenge for preclinical researchers, as
existing models fail to reliably recapitulate all of the classic features of the disease, namely …
existing models fail to reliably recapitulate all of the classic features of the disease, namely …
α-Synuclein and nonhuman primate models of Parkinson's disease
SC Vermilyea, ME Emborg - Journal of neuroscience methods, 2015 - Elsevier
Accumulation of α-synuclein (α-syn) leading to the formation of insoluble intracellular
aggregates named Lewy bodies is proposed to have a significant role in Parkinson's …
aggregates named Lewy bodies is proposed to have a significant role in Parkinson's …
Studies of depression-related states in animal models of Parkinsonism
N Schintu, X Zhang… - Journal of Parkinson's …, 2012 - content.iospress.com
The diagnosis of Parkinson's disease (PD) is solely based on movement disorders, but
several non-motor deficits are common in PD. Depression often precedes the movement …
several non-motor deficits are common in PD. Depression often precedes the movement …
Concurrent silent strokes impair motor function by limiting behavioral compensation
J Faraji, K Kurio, GA Metz - Experimental neurology, 2012 - Elsevier
Silent strokes occur more frequently than classic strokes; however, symptoms may go
unreported in spite of lasting tissue damage. A silent stroke may indicate elevated …
unreported in spite of lasting tissue damage. A silent stroke may indicate elevated …
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease
J Proft, J Faraji, JC Robbins, FCR Zucchi, X Zhao… - PloS one, 2011 - journals.plos.org
Parkinson's disease (PD) is a common neurodegenerative disease characterized by the loss
of dopaminergic neurons in the substantia nigra and the aggregation of α-synuclein into …
of dopaminergic neurons in the substantia nigra and the aggregation of α-synuclein into …
[HTML][HTML] Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells
HJ Park, HJ Kim - Molecular Medicine Reports, 2013 - spandidos-publications.com
Previous studies have demonstrated that calcium channel blockers have protective effects
on damaged brains. In the present study, the protective effect of the calcium channel blocker …
on damaged brains. In the present study, the protective effect of the calcium channel blocker …