Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …

Vitamin C is an important nutrient implicated in different physiological functions in humans.
Despite its important biological functions, therapeutic applications of vitamin C are rare and …

In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …

Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of
isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in …

The role of vitamin C in the treatment of cancer has been subject to controversy for decades.
Within the past 10 years, mechanistic insight into the importance of vitamin C in epigenetic …

Abstract D-2-hydroxyglutarate (D-2-HG) accumulates in patients with acute myeloid
leukemia (AML) with mutated isocitrate dehydrogenase (IDH) and in other malignancies. D …

It has recently been proven that epigenetic dysregulation is importantly involved in cell
transformation and therefore induces cancerous diseases. The development of molecules …

The epigenetic memory stored in the dynamic modifications, such as base modifications of
cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes …

Simple Summary Vitamin C is an indispensable micronutrient in the human diet due to the
multiple functions it carries out in the body. Reports of clinical studies have indicated that …