Estimation of kidney function is often part of daily clinical practice, mostly done by using the
endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A …

Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …

Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …

Background Due to the asymptomatic nature of the early stages, chronic kidney disease
(CKD) is usually diagnosed at late stages and lacks targeted therapy, highlighting the need …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

Renal transplantation is currently the treatment of choice for end-stage kidney disease,
enabling a quality of life superior to dialysis. Despite this, all transplanted patients are at risk …

Kidney disease is a leading cause of death worldwide. Currently, the diagnosis of kidney
diseases and the grading of their severity are mainly based on clinical features, which do not …

Background Proteomic techniques have facilitated understanding of pathways that mediate
decline in GFR. Albuminuria is a key component of CKD diagnosis, staging, and prognosis …

Abstract Background Type 2 diabetes (T2D) is a complex metabolic ailment marked by a
global high prevalence and significant attention in primary healthcare settings due to its …