Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …

Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. To …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process
common to highly proliferative cells in which glucose is fermented into lactate rather than …

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Cancer metastasis accounts for the major cause of cancer-related deaths. How
disseminated cancer cells cope with hostile microenvironments in secondary site for full …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and
regulatory subsets. CD4+ effector T cell (Teff)(Th1 and Th17) and Treg subsets are …