Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Biomarkers of migraine: an integrated evaluation of preclinical and clinical findings

C Demartini, M Francavilla, AM Zanaboni… - International journal of …, 2023 - mdpi.com
In recent years, numerous efforts have been made to identify reliable biomarkers useful in
migraine diagnosis and progression or associated with the response to a specific treatment …

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

H Zheng, YZ Shi, JT Liang, LL Lu… - Frontiers in pharmacology, 2023 - frontiersin.org
Objective: To examine the causal effect of potentially modifiable risk factors contributing to
migraine pathogenesis. Methods: We performed Mendelian randomization analyses and …

Involvements of hyperhomocysteinemia in neurological disorders

M Cordaro, R Siracusa, R Fusco, S Cuzzocrea… - Metabolites, 2021 - mdpi.com
Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads
to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite …

Migraine in transient global amnesia: a meta-analysis of observational studies

I Liampas, AS Siouras, V Siokas, Z Tsouris, D Rikos… - Journal of …, 2022 - Springer
Abstract Background Purpose Although many studies have investigated the relationship
between transient global amnesia (TGA) and migraine, to date, no meta-analysis has …

Hyperhomocysteinemia increases cortical excitability and aggravates mechanical hyperalgesia and anxiety in a nitroglycerine-induced migraine model in rats

E Gerasimova, O Yakovleva, D Enikeev, K Bogatova… - Biomolecules, 2022 - mdpi.com
Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic effects at
high concentrations. Population studies suggest an association between plasma …

Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features

M Papasavva, M Vikelis, V Siokas, MS Katsarou… - Frontiers in …, 2023 - frontiersin.org
Introduction Migraine is a complex disorder with genetic and environmental inputs.
Cumulative evidence implicates oxidative stress (OS) in migraine pathophysiology while …

Targeting glutamate neurotoxicity through dietary manipulation: Potential treatment for migraine

F Martami, KF Holton - Nutrients, 2023 - mdpi.com
Glutamate, the main excitatory neurotransmitter in the central nervous system, is implicated
in both the initiation of migraine as well as central sensitization, which increases the …

Truths and myths in pediatric migraine and nutrition

L Papetti, R Moavero, MAN Ferilli, G Sforza… - Nutrients, 2021 - mdpi.com
The link between migraine and nutrition can be explored from several points of view.
Lifestyle and, in particular, aspects of nutrition can have a significant impact on the course of …

Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats

E Gerasimova, G Burkhanova, K Chernova… - Behavioural brain …, 2021 - Elsevier
Epidemiological data suggest that elevated homocysteine is associated with migraine with
aura. However, how homocysteine contributes to migraine is still unclear. Here, we tested …