The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …

Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the
adaptive inflammatory immune response leading to the rejection of allogeneic transplants …

Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the
vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late …

Transplantation of allogeneic organs and tissues represents a lifesaving procedure for a
variety of patients affected with end-stage diseases. Although current immunosuppressive …

Abstract CD4+ CD25+ regulatory T (Treg) cells play a critical role in the induction and
maintenance of peripheral immune tolerance. In experimental transplantation models in …

Recent advances indicate that, in various chronic inflammatory disorders, the activation of
the immune system is triggered locally rather than in lymphoid organs. In this study, we have …

It has long been appreciated that MHC alloantigens can be recognized via two pathways;
direct and indirect. The relative contributions of these two pathways to transplant rejection …

Alloimmune T cells are central mediators of rejection and graft-versus-host disease in both
solid organ and hematopoietic stem cell transplantation. Unique among immune responses …

Recent evidence suggests that a population of professional regulatory cells, which limit
immune responsiveness, exist in rodents and healthy human subjects. However, their role in …