As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial
tissues, laminin is a very abundant extracellular matrix component and a key supporting …

Chromatin is a unique structure of DNA and histone proteins in the cell nucleus and the site
of dynamic regulation of gene expression. Soluble factors are known to affect the chromatin …

Background: Increased cancer rates denote that one in two people will be diagnosed with
cancer in their lifetime. Over 60% of cancer patients receive radiotherapy, either as a stand …

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by
mechanotransduction. However, it is still unclear how cells sense and transduce the …

For patients exhibiting non-small-cell lung cancer (NSCLC) with activating epidermal growth
factor receptor (EGFR) mutations, epidermal growth factor receptor tyrosine kinase inhibitors …

Bone regenerative biomaterials are essential in treating bone defects by supplying
fundamental extracellular substrates where cells can adhere, proliferate, and differentiate …

Tissue development is mediated by a combination of mechanical and biological signals.
Currently, there are many reports on biological signals regulating repair. However …

Single-molecule localization microscopy (SMLM) can provide nanoscale resolution in thin
samples but has rarely been applied to tissues because of high background from out-of …