Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …

Ferritin is one of the most frequently requested laboratory tests in primary and secondary
care, and levels often deviate from reference ranges. Serving as an indirect marker for total …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

Summary Ludwig van Beethoven (1770–1827) remains among the most influential and
popular classical music composers. Health problems significantly impacted his career as a …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …

Iron overload in humans is associated with a variety of genetic and acquired conditions. Of
these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined …

Steatosis of the liver may arise from a variety of conditions, but the molecular basis for lipid
droplet formation is poorly understood. Although a certain amount of lipid storage may even …

Haemochromatosis is characterised by elevated transferrin saturation (TSAT) and
progressive iron loading that mainly affects the liver. Early diagnosis and treatment by …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …