The potential of chitosan in nanomedicine: An overview of the cytotoxicity of chitosan based nanoparticles

J Frigaard, JL Jensen, HK Galtung… - Frontiers in …, 2022 - frontiersin.org
The unique properties and applications of nanotechnology in targeting drug delivery,
cosmetics, fabrics, water treatment and food packaging have received increased focus the …

Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …

Chitosan-based nanomaterial as immune adjuvant and delivery carrier for vaccines

X Gong, Y Gao, J Shu, C Zhang, K Zhao - Vaccines, 2022 - mdpi.com
With the support of modern biotechnology, vaccine technology continues to iterate. The
safety and efficacy of vaccines are some of the most important areas of development in the …

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

S Mallakpour, E Azadi, CM Hussain - International Journal of Biological …, 2021 - Elsevier
Pathogen transmission is a widespread threat to global human health. Vaccines are very
important during the outbreak of a pandemic. Destructive fractures caused by a sudden …

Chitosan nanoparticles: shedding light on immunotoxicity and hemocompatibility

S Jesus, AP Marques, A Duarte, E Soares… - … in bioengineering and …, 2020 - frontiersin.org
Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the
number of studies including NPs are growing over the last years, their side effects on the …

Design and application of nanoparticles as vaccine adjuvants against human corona virus infection

L Mao, Z Chen, Y Wang, C Chen - Journal of inorganic biochemistry, 2021 - Elsevier
In recent years, some viruses have caused a grave crisis to global public health, especially
the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines …

Strategies for the preparation of chitosan derivatives for antimicrobial, drug delivery, and agricultural applications: A review

R Shrestha, A Thenissery, R Khupse, G Rajashekara - Molecules, 2023 - mdpi.com
Chitosan has received much attention for its role in designing and developing novel
derivatives as well as its applications across a broad spectrum of biological and …

Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles

EA Grego, AC Siddoway, M Uz, L Liu… - … for Rational Vaccine …, 2020 - Springer
As vaccine formulations have progressed from including live or attenuated strains of
pathogenic components for enhanced safety, developing new adjuvants to more effectively …

Mast cell functions linking innate sensing to adaptive immunity

K Katsoulis-Dimitriou, J Kotrba, M Voss, J Dudeck… - Cells, 2020 - mdpi.com
Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is
increasing evidence for their critical role in host defense. MCs not only play an important role …

How the lack of chitosan characterization precludes implementation of the safe-by-design concept

C Marques, C Som, M Schmutz, O Borges… - … in bioengineering and …, 2020 - frontiersin.org
Efficacy and safety of nanomedicines based on polymeric (bio) materials will benefit from a
rational implementation of a Safe-by-Design (SbD) approach throughout their development …