[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …
omics technologies are increasingly being used to develop health and treatment …
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …
of spaceflight on the human body. Biospecimen samples were collected from four crew …
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Spaceflight induces molecular, cellular, and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Background Spaceflight poses a unique set of challenges to humans and the hostile
spaceflight environment can induce a wide range of increased health risks, including …
spaceflight environment can induce a wide range of increased health risks, including …
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
JS Garcia-Medina, K Sienkiewicz… - Precision Clinical …, 2024 - academic.oup.com
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …
investigated the physiological effects of short-duration spaceflight through a multi-omic …
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for
maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long …
maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long …