Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with
interesting biological activities. This review focuses on the synthetic strategies for the …

In the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of
new heterocyclic compounds with several pharmacological properties, so the search for new …

Copper-catalyzed cascade cyclization reactions between alkenyl boronic esters and N–H-
based nucleophiles have been established, providing new approaches for one-pot …

The direct catalytic alkynylation/dehydrative cyclization of 2-amino-3-trifluoroacetyl-pyridines
on water was developed for the efficient synthesis of a broad range of fluorinated 1, 8 …

Quinoline derivatives are an important class of heterocyclic compounds and possess
various applications in synthetic organic chemistry, medicinal chemistry, material chemistry …

We combine random sampling and active machine learning (ML) to optimize the synthesis of
isomacroin, executing only 3% of all possible Friedländer reactions. Employing kinetic …

Coumarins (natural, as well as synthetic) are an important class of heterocycles having
immense potential for industrial and medicinal applications. Coumarin-fused heterocycles …

In this work, 2-alkyl-10-chloro-1, 2, 3, 4-tetrahydrobenzo [b][1, 6] naphthyridines were
obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including …

An efficient, one-pot, and catalyst-free pathway was reported for the synthesis of novel
chromeno [1, 6] naphthyridine derivatives via a multicomponent condensation reaction of …

An interest for the development of new 2‐acetyl/propanoyl quinolines via Friedländer
synthesis is one of the most studied synthetic approaches. Herein we report the use of a …