Teicoplanin (Tcp) is a clinically relevant glycopeptide antibiotic (GPA) that is produced by
the actinobacterium Actinoplanes teichomyceticus. Tcp is a front-line therapy for treating …

This mini-review is centered on genetic aspects of biosynthesis of landomycins (La), a family
of angucycline polyketides. From the very discovery in the 1990s, La were noted for unusual …

Actinobacteria are among the most prolific sources of medically and agriculturally important
compounds, derived from their biosynthetic gene clusters (BGCs) for specialized …

The transcription factor AdpA is a key regulator controlling both secondary metabolism and
morphological differentiation in Streptomyces. Due to its critical functions, its expression …

Rehmannia glutinosa, a valuable medicinal plant, is threatened by ring rot, a condition that
greatly affects its yield and quality. Interactions between plant and the rhizosphere soil …

Background AdpA is a global regulator of morphological differentiation and secondary
metabolism in Streptomyces, but the regulatory roles of the Streptomyces AdpA family on the …

Members of actinobacterial genus Streptomyces possess a sophisticated life cycle and are
the deepest source of bioactive secondary metabolites. Although morphogenesis and …

Fidaxomicin, an 18-membered macrolide antibiotic, is highly active against Clostridium
difficile, the most common cause of diarrhea in hospitalized patients. Though the …

Streptomycesároseochromogenes NRRL 3504 is best known as a producer of clorobiocin, a
DNA replication inhibitor from the aminocoumarin family of antibiotics. This natural product …

Streptomyces species are important antibiotic-producing organisms that tightly regulate their
antibiotic production. Actinorhodin is a typical antibiotic produced by the model actinomycete …