Immunotherapy: building a bridge to a cure for type 1 diabetes
JA Bluestone, JH Buckner, KC Herold - Science, 2021 - science.org
Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …
[HTML][HTML] Targeting immune dysfunction in aging
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …
cellular processes, with the immune system being one of the most dysregulated …
[HTML][HTML] Genetic engineering of T cells for immunotherapy
Genetically engineered T cell immunotherapies have provided remarkable clinical success
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
SJ Yang, AK Singh, T Drow, T Tappen… - Science Translational …, 2022 - science.org
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
An evolved AAV variant enables efficient genetic engineering of murine T cells
Precise targeting of large transgenes to T cells using homology-directed repair has been
transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via …
transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via …
The emerging role of regulatory cell-based therapy in autoimmune disease
F Ghobadinezhad, N Ebrahimi, F Mozaffari… - Frontiers in …, 2022 - frontiersin.org
Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …
millions of people each year and poses a great social and economic burden to individuals …
Emerging therapeutics for immune tolerance: tolerogenic vaccines, T cell therapy, and IL-2 therapy
CD Moorman, SJ Sohn, H Phee - Frontiers in immunology, 2021 - frontiersin.org
Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …
Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation
C Selck, M Dominguez-Villar - Frontiers in immunology, 2021 - frontiersin.org
Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …
Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential
S Yan, K Kotschenreuther, S Deng… - Cellular and molecular life …, 2022 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …
mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies
Cell-based therapies for autoimmune diseases have gained significant traction, with several
approaches centered around the regulatory T (Treg) cell─ a well-known …
approaches centered around the regulatory T (Treg) cell─ a well-known …