Targeting epigenetic aberrations of sarcoma in CRISPR era
M Tanaka, T Nakamura - Genes, Chromosomes and Cancer, 2023 - Wiley Online Library
Sarcomas are rare malignancies that exhibit diverse biological, genetic, morphological, and
clinical characteristics. Genetic alterations, such as gene fusions, mutations in transcriptional …
clinical characteristics. Genetic alterations, such as gene fusions, mutations in transcriptional …
Epigenetic determinants of fusion-driven sarcomas: paradigms and challenges
BZ Stanton, S Pomella - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …
epigenetics perspective. By exploring the current state of the field, we identify and describe …
[HTML][HTML] SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis
R Iyer, A Deshpande, A Pedgaonkar, PA Bala, T Kim… - …, 2024 - pmc.ncbi.nlm.nih.gov
Synovial Sarcoma (SySa) is an aggressive soft tissue sarcoma that accounts for 5–10% of
all soft tissue sarcomas. Current treatment involves radiation and radical surgery including …
all soft tissue sarcomas. Current treatment involves radiation and radical surgery including …