Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …

G protein-coupled receptors (GPCRs) are the major class of sensory proteins and a primary
therapeutic target in the pathways to pain and itch. GPCRs are complex signaling machines …

G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are
most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Neutrophils are peripheral immune cells that represent the first recruited innate immune
defense against infections and tissue injury. However, these cells can also induce …

The C5a receptor (C5aR) is a G-protein-coupled receptor (GPCR) that can induce strong
inflammatory response to the anaphylatoxin C5a. Targeting C5aR has emerged as a novel …

Complement factor C5a is an integral constituent of the complement cascade critically
involved in the innate immune response, and it exerts its functions via two distinct receptors …