An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
Ivermectin for preventing and treating COVID‐19
M Popp, M Stegemann, MI Metzendorf… - Cochrane Database …, 2021 - cochranelibrary.com
Background Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the
replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of …
replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of …
[HTML][HTML] Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
F Heidary, R Gharebaghi - The Journal of antibiotics, 2020 - nature.com
Ivermectin proposes many potentials effects to treat a range of diseases, with its
antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective …
antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective …
[HTML][HTML] The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Although several clinical trials are now underway to test possible therapies, the worldwide
response to the COVID-19 outbreak has been largely limited to monitoring/containment. We …
response to the COVID-19 outbreak has been largely limited to monitoring/containment. We …
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer
SNY Yang, SC Atkinson, C Wang, A Lee… - Antiviral research, 2020 - Elsevier
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and
dengue virus (DENV) represent a major burden for human health worldwide. Although RNA …
dengue virus (DENV) represent a major burden for human health worldwide. Although RNA …
Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects
G El-Saber Batiha, A Alqahtani, OB Ilesanmi, AA Saati… - Pharmaceuticals, 2020 - mdpi.com
Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
Ivermectin: an anthelmintic, an insecticide, and much more
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and
recent studies that have sought to reposition ivermectin for the treatment of other diseases …
recent studies that have sought to reposition ivermectin for the treatment of other diseases …
[HTML][HTML] Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic
A Elgazzar, A Eltaweel, SA Youssef, B Hany, M Hafez… - 2020 - europepmc.org
Background: Up-to-date, there is no recognized effective treatment or vaccine for the
treatment of COVID-19 that emphasize urgency around distinctive effective therapies. This …
treatment of COVID-19 that emphasize urgency around distinctive effective therapies. This …
Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial
Objective We evaluated whether ivermectin combined with doxycycline reduced the clinical
recovery time in adults with COVID-19 infection. Methods This was a randomized, blinded …
recovery time in adults with COVID-19 infection. Methods This was a randomized, blinded …