Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …

Endogenous and exogenous neurotoxins are important factors leading to
neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1, 2, 3, 6 …

Tauopathies such as Alzheimer's and Parkinson's diseases involve the abnormal deposition
of tau aggregates in the brain and neuronal tissues. We report that a natural …

Atomic force microscopy (AFM) is a scanning probe microscopy technique which has a
physical principle, the measurement of interatomic forces between a very thin tip and the …

Despite the many mechanisms it has created to prevent unfolding and aggregation of
proteins, many diseases are caused by abnormal folding of proteins, which are called …

Plumbagin, a hydroxy-1, 4-naphthoquinone, confers neuroprotection via antioxidant and anti-
inflammatory properties. The present study aimed to assess the effect of plumbagin on …

One of the recognized motor neuron degenerative disorders is amyotrophic lateral sclerosis
(ALS). By now, several mutations have been reported and linked to ALS patients, some of …

Abstract Kynurenine-3-monooxygenase (KMO) is an important therapeutic target for several
brain disorders that has been extensively studied in recent years. Potent inhibitors towards …

One of the major problems caused by repeated subcutaneous insulin injections in patients
with diabetes is insulin amyloidosis. Understanding the molecular mechanism of amyloid …