Novel druggable mechanism of Parkinson's disease: potential therapeutics and underlying pathogenesis based on ferroptosis
Genetics, age, environmental factors, and oxidative stress have all been implicated in the
development of Parkinson's disease (PD); however, a complete understanding of its …
development of Parkinson's disease (PD); however, a complete understanding of its …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …
An overview of the pathophysiological mechanisms of 3-nitropropionic acid (3-NPA) as a neurotoxin in a huntington's disease model and its relevance to drug …
S Upadhayay, NG Yedke, V Rahi, S Singh… - Neurochemical …, 2023 - Springer
Animal models are used to better understand the various mechanisms involved in the
pathogenesis of diseases and explore potential pathways that will aid in discovering …
pathogenesis of diseases and explore potential pathways that will aid in discovering …
'Mechanistic insights into 5-lipoxygenase inhibition by active principles derived from essential oils of Curcuma species: Molecular docking, ADMET analysis and …
Inflammation is caused by a cascade of events, one of which is the metabolism of
arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase. 5-Lipoxygenase …
arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase. 5-Lipoxygenase …
Novel 5, 6-diphenyl-1, 2, 4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity
Abstract A novel series of 5, 6-diphenyl-1, 2, 4-triazine-3-thiol derivatives were designed,
synthesized, and screened for their inhibitory potential against COX-2 and 5-LOX enzymes …
synthesized, and screened for their inhibitory potential against COX-2 and 5-LOX enzymes …
Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5-LOX by molecular docking and dynamic …
Inflammation plays a pivotal role in various pathological processes, ranging from routine
injuries and infections to cancer. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) …
injuries and infections to cancer. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) …
Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis
Osteoarthritis (OA) is a disease due to the aging of the articular cartilage, a post‐mitotic
tissue that stays functioning until primary homeostatic processes fail. Because of pain and …
tissue that stays functioning until primary homeostatic processes fail. Because of pain and …
Plasma oxylipin profiles reflect Parkinson's disease stage
DV Chistyakov, NV Azbukina, AV Lopachev… - Prostaglandins & Other …, 2024 - Elsevier
Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key
participants in regulating inflammation. Neuroinflammation is involved in many …
participants in regulating inflammation. Neuroinflammation is involved in many …
Neuroaxonal and cellular damage/protection by prostanoid receptor ligands, fatty acid derivatives and associated enzyme inhibitors
NA Sharif - Neural Regeneration Research, 2023 - journals.lww.com
Cellular and mitochondrial membrane phospholipids provide the substrate for synthesis and
release of prostaglandins in response to certain chemical, mechanical, noxious and other …
release of prostaglandins in response to certain chemical, mechanical, noxious and other …