In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …

The twenty-first century is presenting humankind with unprecedented environmental and
medical challenges. The ability to design novel proteins tailored for specific purposes would …

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …

Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …

Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …

Histone modifications, such as the frequently occurring lysine succinylation,, are central to
the regulation of chromatin-based processes. However, the mechanism and functional …

Pathogens secrete effector proteins and many operate inside plant cells to enable infection.
Some effectors have been found to enter subcellular compartments by mimicking host …

The intestinal epithelial cells (IECs) constitute the primary barrier between host cells and
numerous foreign antigens; it is unclear how IECs induce the protective immunity against …