Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Unfolded protein response (UPR) of the endoplasmic reticulum (UPRER) helps maintain
proteostasis in the cell. The ability to mount an effective UPRER to external stress (iUPRER) …

Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …

In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that
the nuclear hormone receptor, NHR-49, enables the response to this physiological change …

Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in
lifespan extension are not clear. Here, by using the nematode C. elegans, we identified that …

Endogenous and exogenous stresses elicit transcriptional responses that limit damage and
promote cell/organismal survival. Like its mammalian counterparts, hepatocyte nuclear …

Nanopolystyrene particles can cause the adverse effects on environmental organisms.
Using Caenorhabditis elegans as an animal model, we found that prolonged exposure to …

Dietary restriction (DR) interventions have demonstrated their efficacy in extending lifespan;
however, the association between lifespan extension and health span remains unclear. This …

Alternative splicing (AS) coupled to nonsense-mediated decay (AS-NMD) is a conserved
mechanism for post-transcriptional gene regulation. Here we show that, during dietary …