Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …

Botulinum Neurotoxins (BoNTs) are a large protein family that includes the most potent
neurotoxins known to humankind. BoNTs delivered locally in humans at low doses are …

The design of neural electrodes has changed in the past decade, driven mainly by the
development of new materials that open the possibility of manufacturing electrodes with …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …

Using paired-end RNA sequencing, we have quantified the deep transcriptional changes
that occur during differentiation of murine embryonic stem cells into a highly enriched …

Mitogen-activated protein kinases (MAPKs) are essential players in important neuronal
signaling pathways including neuronal development, plasticity, survival, learning, and …

Minor and major spliceosomes control splicing of distinct intron types and are thought to act
largely independent of one another. SR proteins are essential splicing regulators mostly …

Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic
compartments with exquisite specificity. While the native toxin is extremely lethal …

We previously reported that the pseudophosphatase MK-STYX (mitogen activated kinase
phosphoserine/threonine/tyrosine binding protein) dramatically increases the number of …

Clinical manifestations of tetanus and botulism result from an intricate series of interactions
between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause …