The living world is largely divided into autotrophs that convert CO 2 into biomass and
heterotrophs that consume organic compounds. In spite of widespread interest in renewable …

Can a heterotrophic organism be evolved to synthesize biomass from CO 2 directly? So far,
non-native carbon fixation in which biomass precursors are synthesized solely from CO 2 …

Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates
gene expression. A useful description of the TRN would decompose the transcriptome into …

Bacteriophages (phages) are critical players in the dynamics and function of microbial
communities and drive processes as diverse as global biogeochemical cycles and human …

The use of alternative translation initiation sites enables production of more than one protein
from a single gene, thereby expanding the cellular proteome. Although several such …

Recent developments in high-throughput reverse genetics, have revolutionized our ability to
map gene function and interactions,,–. The power of these approaches depends on their …

Microbial interactions are expected to be major determinants of microbiome structure and
function. Although fungi are found in diverse microbiomes, their interactions with bacteria …

Urban wastewater treatment plants (UWTPs) are among the main hotspots of antibiotic
resistance (AR) spread into the environment and the role of conventional and new …

Organisms orchestrate cellular functions through transcription factor (TF) interactions with
their target genes, although these regulatory relationships are largely unknown in most …

Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the
alarmone (p) ppGpp, a nucleotide second messenger.(p) ppGpp rewires bacterial …