The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …

Our research laboratory has a longstanding interest in developmental disorders and
embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver …

Previous studies described the involvement of extracellular signal-related kinase (ERK) in
systemic fibrotic diseases, but the role of ERK in cutaneous scarring is unknown. Although …

Background WD repeat domain 3 (WDR3) is involved in a variety of cellular processes
including gene regulation, cell cycle progression, signal transduction and apoptosis …

The AHNAK family currently consists of two members, namely AHNAK and AHNAK2, both of
which have a molecular weight exceeding 600 kDa. Homologous sequences account for …

Simple Summary The childhood tumor, neuroblastoma, has a broad clinical presentation.
Risk assessment at diagnosis is particularly difficult in molecularly heterogeneous high-risk …

RNA polymerase III (pol III) products play fundamental roles in a variety of cellular
processes, including protein synthesis and cancer cell proliferation. In addition …

Abstract Background and Aim The high mortality and poor prognosis of hepatocellular
carcinoma (HCC) have raised the public attention. Gene therapy is considered as a …

The failure of therapies directed at targets within cancer cells highlight the necessity for a
paradigm change in cancer therapy. The attention of researchers has shifted towards the …