Antibiotic perturbations to the gut microbiome
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …
generally associated with drug target modification, enzymatic inactivation, and/or transport …
Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: roles and mechanisms
The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …
Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes
It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
antimicrobial resistance (AMR) genes; however, little is known about the role of the …
Horizontal transfer of antibiotic resistance genes in clinical environments
NA Lerminiaux, ADS Cameron - Canadian journal of …, 2019 - cdnsciencepub.com
A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …
Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer
Antimicrobial resistance (AMR) poses a worldwide threat to human health and biosecurity.
The spread of antibiotic resistance genes (ARGs) via conjugative plasmid transfer is a major …
The spread of antibiotic resistance genes (ARGs) via conjugative plasmid transfer is a major …
Programmable synthetic biomolecular condensates for cellular control
The formation of biomolecular condensates mediated by a coupling of associative and
segregative phase transitions plays a critical role in controlling diverse cellular functions in …
segregative phase transitions plays a critical role in controlling diverse cellular functions in …
Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
Deciphering the mobility and bacterial hosts of antibiotic resistance genes under antibiotic selection pressure by metagenomic assembly and binning approaches
The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …