Mastocytosis and mast cell activation disorders: clearing the air

CW Jackson, CM Pratt, CP Rupprecht… - International journal of …, 2021 - mdpi.com
Mast cells are derived from hematopoietic stem cell precursors and are essential to the
genesis and manifestations of the allergic response. Activation of these cells by allergens …

Prediction of subclinical and clinical multiple organ failure dysfunction in breast cancer patients—a review using AI tools

AI Ionescu, DI Atasiei, RT Ionescu, F Ultimescu… - Cancers, 2024 - mdpi.com
Simple Summary The paper discusses precursor lesions of breast cancer and the
subclinical syndrome of multiple organ failure, representing early disease stages with …

KIT mutations and other genetic defects in mastocytosis: implications for disease pathology and targeted therapies

Y Chantran, P Valent, M Arock - … and Allergy Clinics, 2023 - immunology.theclinics.com
Mastocytosis is a group of rare diseases characterized by abnormal expansion of neoplastic
mast cells (MC) in at least one organ/tissue, mainly skin, bone marrow (BM), and …

Diffuse Cutaneous Mastocytosis: A Current Understanding of a Rare Disease

A Rydz, M Lange, H Ługowska-Umer… - International Journal of …, 2024 - mdpi.com
Mastocytosis is a heterogeneous disease characterized by the expansion and accumulation
of neoplastic mast cells in various tissues. Diffuse cutaneous mastocytosis (DCM) is a rare …

Repositioning drugs for rare diseases based on biological features and computational approaches

B Otero-Carrasco, L Prieto Santamaría, E Ugarte Carro… - Healthcare, 2022 - mdpi.com
Rare diseases are a group of uncommon diseases in the world population. To date, about
7000 rare diseases have been documented. However, most of them do not have a known …

Cutaneous Mastocytosis in Childhood: An Update from the Literature

Ö Özdemir, S Savasan - Journal of Clinical Practice and Research, 2023 - jcpres.com
Mastocytosis is an uncommon disease characterized by clonal infiltration of mast cell (MC)
in different tissues. Cutaneous mastocytosis (CM) is the most frequent type observed during …

Current Challenges in the Diagnosis of Pediatric Cutaneous Mastocytosis

H Ługowska-Umer, J Czarny, A Rydz, RJ Nowicki… - Diagnostics, 2023 - mdpi.com
Pediatric mastocytosis is mostly a cutaneous disease classified as cutaneous mastocytosis
(CM), which is characterized by mast cell (MCs) accumulation in the skin and the absence of …

The many faces of pediatric urticaria

BE Sekerel, D Ilgun Gurel, UM Sahiner, O Soyer… - Frontiers in …, 2023 - frontiersin.org
Urticaria is a common disease that can affect individuals of all age groups, with
approximately one-quarter of the population experiencing it at least once in their lifetime …

Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and …

AI Ionescu, AV Anghel, IL Antone-Iordache… - Journal of Personalized …, 2024 - mdpi.com
Breast cancer (BC) significantly impacts the quality of life (QoL) of affected individuals. This
study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess the impact of …

Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies

AM Radu, M Carsote, C Nistor, MC Dumitrascu… - Biomedicines, 2023 - mdpi.com
In this narrative review, we aimed to overview the interplay between lichen planus (LP) and
thyroid conditions (TCs) from a dual perspective (dermatologic and endocrine), since a …