Cancer is a multifactorial disease produced by mutations in the oncogenes and tumor
suppressor genes, which result in uncontrolled cell proliferation and resistance to cell death …

Impressive advances have been made to replicate human physiology in vitro over the last
few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic …

Amyotrophic lateral sclerosis (ALS) is a progressive and devastating neurodegenerative
disorder characterized by the loss of upper and lower motor neurons, resulting in debilitating …

To date, genetically modified organoids are emerging as a promising 3D modeling tool
aimed at solving genetically relevant clinical and biomedical problems for regenerative …

Organ-on-a-chip technology is considered a next-generation platform in pharmacology and
toxicology. Nevertheless, this novel technology still faces several challenges concerning the …

Drug discovery for complex liver diseases faces alarming attrition rates. The lack of non-
clinical models that recapitulate key aspects of liver (patho)-physiology is likely contributing …

Background Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair
present high mortality and increased risk of acute kidney injury (AKI)-chronic kidney disease …

ABSTRACT Bone‐on‐a‐chip (BOC) models that based on microfluidic technology have
widely applied to understand bone physiology and the pathogenesis of related diseases. In …

Introduction Vascular diseases impart a tremendous burden on healthcare systems in the
United States and across the world. Efforts to improve therapeutic interventions are hindered …

Background In the management of complex diseases, the strategic adoption of combination
therapy has gained considerable prominence. Combination therapy not only holds the …