BioID has become an increasingly utilized tool for identifying candidate protein–protein
interactions (PPIs) in living cells. This method utilizes a promiscuous biotin ligase, called …

The non-catalytic region of tyrosine kinase (Nck) family of adaptors, consisting of Nck1 and
Nck2, contributes to selectivity and specificity in the flow of cellular information by recruiting …

The Nck family of modular adaptor proteins, including Nck1 and Nck2, link phosphotyrosine
signaling to changes in cytoskeletal dynamics and gene expression that critically modulate …

Eph receptors and their ephrin ligands are viewed as promising targets for cancer treatment;
however, targeting them is hindered by their context-dependent functionalities. To …

EPH receptors (EPHRs) constitute the largest family among receptor tyrosine kinases in
humans. They are mainly involved in short-range cell-cell communication events that …

The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate
diverse biological processes including cell proliferation and actin dynamics in many tissue …

Protein clustering is a ubiquitous event in diverse cellular processes. Self‐association of
proteins triggers recruitment of downstream proteins to regulate cellular signaling. To …

Background Maintenance of the kidney filtration barrier requires coordinated interactions
between podocytes and the underlying glomerular basement membrane (GBM). GBM …

Although the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)
established the role of treating inflammation in atherosclerosis, our understanding of …

Spontaneous mutations in the EEF1A2 gene cause epilepsy and severe neurological
disabilities in children. The crystal structure of eEF1A2 protein purified from rabbit skeletal …