The past, present, and future of antibiotics
MA Cook, GD Wright - Science translational medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …
diseases and enable vital therapies and procedures. However, despite this success, their …
Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments
N Ahmad-Mansour, P Loubet, C Pouget… - Toxins, 2021 - mdpi.com
Staphylococcus aureus is a clinically important pathogen that causes a wide range of
human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus …
human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus …
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans
YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …
vaccines, there remains a need for more prevention and treatment options for individuals …
Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia
Respiratory microbial dysbiosis is associated with acute respiratory distress syndrome
(ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack …
(ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack …
Alternative therapeutic strategies to treat antibiotic-resistant pathogens
CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …
ineffective, thus posing a threat to human health. The discovery of novel classes of …
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin
AN Spaan, AL Neehus, E Laplantine, F Staels… - Science, 2022 - science.org
The molecular basis of interindividual clinical variability upon infection with Staphylococcus
aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase …
aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase …
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa …
J Chastre, B François, M Bourgeois, A Komnos… - Critical Care, 2022 - Springer
Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in
hospitalised patients is associated with high mortality. The effectiveness of the bivalent …
hospitalised patients is associated with high mortality. The effectiveness of the bivalent …
Bacterial keratitis: identifying the areas of clinical uncertainty
S Tuft, TF Somerville, JPO Li, T Neal, S De… - Progress in retinal and …, 2022 - Elsevier
Bacterial keratitis is a common corneal infection that is treated with topical antimicrobials. By
the time of presentation there may already be severe visual loss from corneal ulceration and …
the time of presentation there may already be severe visual loss from corneal ulceration and …
The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic
D Reynolds, JP Burnham, CV Guillamet… - European …, 2022 - Eur Respiratory Soc
Antibiotic resistance is recognised as a global threat to human health by national healthcare
agencies, governments and medical societies, as well as the World Health Organization …
agencies, governments and medical societies, as well as the World Health Organization …